The Breakthrough

"The Breakthrough not only provides good background and good understanding for patients, but is also a wonderful read, a book easily picked up but not easily put down -- I'd recommend it for any patient interested in immunology of cancer."

"THE BREAKTHROUGH artfully traces the history of old and new developments that may have -- finally -- resulted in an actual cure for the most dreaded of all diseases. This book and the advances it describes offer far more than the usual glimmer of hope...Graeber does a good job of hacking through it all, interspersing the medical research with interesting accounts of patients and their determined physicians."

"A gripping chronicle of the 100-year overnight success of Immunotherapy. For myself and millions of other cancer survivors, THE BREAKTHROUGH is a book of immense and essential hope."

"Only Graeber, one of America's greatest non-fiction writers, could take a subject so complex, dense and sprawling and turn it into a rollicking high-tension medical thriller. Masterful."

"There is no villain more ruthless than cancer, which has robbed us all of loved ones who had to endure untold suffering before they succumbed. But after decades of frustration and toil, scientists finally understand how to vanquish the disease by activating the human body's natural defenses. The intimate stories behind this triumph lie at the heart of Charles Graeber's THE BREAKTHROUGH, an expertly crafted and exhilarating account of life-saving ingenuity at its most dazzling. You will never encounter another book so incisive about the art of medical sleuthing, or so poetic about our innate drive to hold on to all that's beautiful in this world for as long as we can."

"Engaging...In Mr. Graeber's hands, the evolution of immuno-oncology is both captivating and heartbreaking. We are immersed in the stories of the brave, desperate patients who try emerging therapies...We can't fail to see ourselves, our friends and our families in these stories."

"Graeber concisely reviews the science of cancer...The risks of tinkering with an intricate immune system are obviously high, even perilous. But the potential reward is a cure. Exciting reading."

"Graeber does it again. He takes a complex topic -- this time advances in cancer treatment -- and weaves an engaging narrative that engages you to the end. With cancer as a leading cause of illness and death, this book is a timely and important account of the challenges and possibilities for new horizons in cancer treatment."

"Lucid and informed...Graeber gives readers a basis for both understanding the challenges involved and for cautious optimism that a cure can be found."

"[A] deft, detailed study of cancer immunotherapy...From the once-discredited pioneer William Coley to immunologist and Nobel laureate James P. Allison, they form a brilliant, driven, admirably stubborn group that Graeber brings vividly to life."

"Crisp and suspenseful...an inspiring medical narrative."

"Fascinating...[Graeber] weaves human stories with accounts of scientific progress, looking beyond the "cut, burn, and poison techniques" -- surgery, radiation, and chemotherapy -- to focus on the myriad ways the immune system can attack cancer, and provides hope that a cure might not be beyond imagination."

"Rare and thrilling...a hopeful, even inspiring, book about cancer."